When a gender diverse child presents for treatment, a biopsychosocial assessment, which often includes developing a treatment relationship with the family over time, is both helpful and necessary. In the absence of an evidence-based intervention, individual risk-benefit analyses that prioritize positive emotional, social, and psychological functioning of the child are crucial in determining the gender-related interventions to support and how they should be implemented. Attendees gain appreciation for cultural, social, psychological, and developmental factors, as well as the presence of mental health disorders, that affect decision-making; understand the ethical considerations and challenges that surround social gender transition for gender diverse pre-pubertal children; and recognize the challenges caregivers face when making decisions about how their child’s gender identity and social gender role affects their overall development.