The main goal of this Clinical Practicum is to familiarize the participants with the clinical practices at the Comprehensive Adolescent Rehabilitation and Education Service (CARES), which provides services for adolescents with high-risk for self-harm behaviors, frequent hospitalizations, escalating substance use, and school drop-outs. This is achieved through a series of lectures by leaders in the fields of public education and translational and clinical psychiatric research, as well as the clinicians at CARES. Additional activities include presentations by CARES teachers, a motivational interviewing interactive workshop, and the opportunity for the attendees to meet and speak with CARES patients. Taken together these activities provide a diverse and highly informative experience and knowledge in relation to the management of high-risk adolescents with severe psychopathology, chronic suicidality, persistent substance use, and educational delays.