Domestic minor sex trafficking (DMST) and commercial sexual exploitation of children are growing problems in the United States. The internet and social networking have made children especially vulnerable to victimization. Child and adolescent psychiatrists must be aware of clinical characteristics of young patients who are victims of DMST. Rhode Island’s position between New York City and Boston, with most of its major metropolitan areas in close proximity to the major traffic artery of Interstate 95, makes it a prime location to examine how cases of DMST unfold. Through case discussions, participants gain a broader understanding of the presentation of DMST, its risk factors, ways to screen for DMST, legal ramifications for these patients, what levels of care these patients require, and how to manage aggression and optimize other interventions in inpatient and outpatient settings.